Authors’ Reply: Vitamin D Sufficiency and COVID-19: Is Vitamin D Binding Protein (and Its Polymorphism) the Missing Link?

      We would like to thank Speeckaert et al
      • Speeckaert M.M.
      • Speeckaert R.
      • Delanghe J.R.
      Vitamin D sufficiency and COVID-19: is vitamin D binding protein (and its polymorphism) the missing link?.
      for their interest in our study and for providing an insightful perspective on vitamin D binding protein (DBP) level or polymorphism as a possible explanation for the association between vitamin D status and coronavirus disease 2019 (COVID-19) outcomes. The authors mentioned their previous study, in which the DBP1 allele frequency, which affects DBP concentration, was associated with lower prevalence and mortality of COVID-19.
      • Speeckaert M.M.
      • Speeckaert R.
      • Delanghe J.R.
      Vitamin D sufficiency and COVID-19: is vitamin D binding protein (and its polymorphism) the missing link?.
      They further brought evidence to support their conclusion that DBP has an independent biological effect on actin scavenging, which is thought to be protective against the development and severity of acute respiratory distress syndrome. Therefore, DBP concentration or certain polymorphisms that affect the circulating concentration of DBP and thus total serum 25-hydroxyvitamin D level might be one of the unaddressed potential confounders in our analysis.

      Abbreviations:

      COVID-19 (coronavirus disease 2019), DBP (vitamin D binding protein)
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